PARKINSON’S IS A GLOBAL PROBLEM

Now there’s an Inspired solution from

Parkinson’s disease (PD) affects over one million Americans. Globally that number increases to 10 million. 90,000 people are diagnosed every year. Our goal is to help every one of them.

PD Attacks Neurons In the Brain

PD patients experience motor symptoms caused by the loss of dopamine neurons in the brain. Even with standard-of-care therapy, symptoms typically worsen over time, including unintended or uncontrollable movements and difficulty with balance and coordination. PD can often appear slowly. In fact, it’s common for PD patients to have lost more than 50% of cells that make dopamine in the affected area of the brain even before diagnosis.

Stem Cell Therapies Have the Potential to Replace Lost Neurons

Aspen specializes in a specific kinds of therapy that are called autologous. Autologous therapies use stem cells that come from the patient’s own tissues instead of from donors or embryonic stem cells. We do this using a technique developed by our co-founders, Dr. Jeanne Loring and Dr. Andres Bratt-Leal, that translates your cells into something called induced Pluripotent Stem Cells (iPSCs).

In simple terms, we take a biopsy, then we give those cells from your body the power to replace your neuronal dopamine cells. Finally, we implant them back into the affected part of your brain to replace the neurons you’ve lost. This autologous approach has a number of benefits, including the fact that your body is more likely to respond positively to therapies that start and end with you.

This groundbreaking process, which combines AI, machine learning, and cutting-edge genomics, has the power to address the critical needs of PD patients around the globe.

It’s been too long since the World has seen a significant step forward in PD treatment. Our platform is designed to change that.

Benefits of autologous therapies:

  • They use the patient’s own cells.
  • These therapies don’t require immunosuppressive drugs to counteract the body’s immune response against foreign tissue.
  • They start with a simple biopsy.
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A Groundbreaking FDA-Approved
Clinical Trial

Our flagship therapy, currently designated ANPD001, aims to replenish lost dopamine neurons using the patient’s own cells. After receiving U.S. FDA clearance, we’ve launched a groundbreaking Phase 1/2a clinical trial for ANPD001.

This is a single-arm, open-label study in patients with moderate to severe Parkinson’s disease in multiple clinical sites in the U.S. This will be a dose-ranging exploratory clinical trial to evaluate the safety, tolerability and preliminary efficacy of different doses of ANPD001.

Aspen has previously performed pre-clinical (nonhuman) studies
demonstrating that its autologous treatment approach reliably
produces dopamine-releasing neurons.

Living With Parkinson’s

If you’re living with PD, there are a few things you can do to improve the likelihood of
successfully navigating PD challenges, regardless of which therapies you’re undergoing.
These include a whole-body wellness program that includes diet, exercise, and emotional health.

HEALTHY EATING SETS YOUR BODY UP FOR SUCCESS

While there is no prescription for a PD-specific diet, the Parkinson’s Foundation recommends most people living with PD eat a balanced diet that incorporates whole grains, vegetables, fruits, milk and dairy products, and proteins like meat and beans.1 Also, consider beneficial fats like fish and nuts, and potentially anti-inflammatory foods. Just like fuel in a car, the fuel your body uses can help it operate at its best.

PRIORITIZE MENTAL HEALTH
ALONG WITH PHYSICAL HEALTH

Depression and anxiety affect up to 50 percent of people living with PD, which can bring on worsening function or a decreased quality of life.2 In other words, a strong foundation of mental health can make a difference in both your treatment and your outcomes. If mental health starts to feel more challenging than usual, consider counseling—alone, as a couple, or as
a family. You also might benefit from support groups, which can offer a venue to share experiences with those on a similar journey.

EXERCISE IS KEY FOR A STRONG BODY AND MIND

Exercise is a vital component for people with PD to
maintain balance, mobility, and daily living activities, along with potential neuroprotective effects.3 Regular exercise boosts mobility, balance, and overall well-being. From treadmill training, yoga, to aerobic exercises, find what suits you. Consistency is the answer, and you don’t have to push yourself
too hard to see the benefits that come from regular physical activity. Aerobic exercise may be especially helpful, as a study of people with early-stage PD who followed a 6-month home-based aerobic exercise program experienced slower worsening of motor symptoms compared with a control group that did not have aerobic exercise.4

SPECIALIZED EXERCISE FOR PEOPLE WITH PD:

Benefits of autologous therapies:

  • They use the patient’s own cells.
  • These therapies don’t require immunosuppressive drugs to counteract the body’s immune response against foreign tissue.
  • They start with a simple biopsy.